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Clinical evidence for Ashwagandha includes several randomized, double-blind, placebo-controlled trials demonstrating reductions in depressive and anxiety symptoms, improved sleep quality, and favorable tolerability, often accompanied by mechanistic signals such as increased serotonin levels and modulation of stress biomarkers

Resveratrol exerts antidepressant properties in the chronic unpredictable mild stress model through the regulation of oxidative stress and mTOR pathway in the rat hippocampus and prefrontal cortex

In addition to the observed increase in mitochondrial fragmentation, the overexpression of FIS1 has also been demonstrated to result in mitochondrial dysfunction and an increase in autophagosome formation (Gomes and Scorrano, 2008)

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